Source: https://tendernation.io/opportunities/01a13ccf-11e5-701f-b437-ab727e6636f2/rq0000010125-epifluorescence-microscope awarded GB open procedure Suitable for SMEs # RQ0000010125 Epifluorescence Microscope [Defence Science and Technology Laboratory](https://tendernation.io/buyers/defence-science-and-technology-laboratory) Open field Estimated value £100,000 Published 15 Mar 2023 Deadline Closed 13 Apr 2023 ## Who can bid - Buyer says suitable for SMEs The buyer ticked “suitable for SMEs” on the notice. Anyone can still bid. - Small contract value Valued under £135,018 including VAT, the lowest Procurement Act threshold for goods and services. - Open procedure Anyone can submit a full tender; there is no shortlisting stage. [More contracts for small businesses and VCSEs](https://tendernation.io/opportunities/for-small-businesses) ## About this tender Intended uses (priority order): - Real-time imaging of cellular physiology using ion-sensitive fluorophores or similar probes (e.g. fura 2 and fluo dyes with ability for acquisition of fura 2 ratiometric images ≥1Hz) - General epifluorescence imaging of living cell cultures using a range of fluorescent dyes to image cellular structure and function (cell viability, mitochondrial function, ROS etc). Excitation/emission capabilities should cover standard range of fluorophores (e.g. DAPI, fluorescein, rhodamine etc). - General transmitted light and epifluorescence imaging of fixed / stained cell cultures and slide-mounted tissue sections Essential requirements: • Research-grade inverted microscope chassis, stage, transmitted light illumination, eyepieces etc • Microscope should be capable of phase and differential interference contrast transmitted light methods. • Objectives 10, 20, 40 and ~60 or 100x optimised for epifluorescence observation and DIC, 20 and 40x objectives optimised for UV excitation for Fura 2 (@340 & 380 nm, if different from standard epifluorescence objectives), additional 20 and 40x for phase contrast. • Epifluorescence light source to provide illumination for cellular physiology studies (excitation suitable for a range of dyes including fura 2) should include software controlled shutter, or equivalent, to control illumination and synchronise to image acquisition. • Epifluorescence light source for general epifluorescence imaging (2 and 3 above) if different • Ability to mount both epifluorescence illumination systems and switch between physiology and high-resolution epifluorescence imaging modes • Monochrome camera suitable for real-time imaging cellular physiology • Monochrome camera for high resolution general epifluorescence (if different from above) • Ability to mount both cameras and switch between physiology and high-resolution epifluorescence imaging modes • Image acquisition and analysis software suitable for running cellular physiology studies • Image acquisition and analysis software suitable for general epifluorescence studies. Ability to combine fluorescence images to produce composite images, ability to undertake image analysis/cytometry measurements of fluorescently labelled specimens. Desirable requirements: • Motorised control of microscope operation • Additional image analysis options for analysis of standard histopathology tissue sections Other: • If all capability is not possible on one microscope chassis then would consider two systems. This requirement will be on the defence sourcing portal (DSP) Additional information: How to apply - This notice can be found on the defence sourcing portal at this link: [contracts.mod.uk/go/172903630186FEB197D9](https://www.contracts.mod.uk/go/172903630186FEB197D9) Read full description ## CPV classification Fluorescent microscopes Source Contracts Finder (UK) [View official notice](https://www.contractsfinder.service.gov.uk/notice/e6585b21-3b0d-4d31-8c28-8f3dc8fa7ec1) Never miss a tender like this again Get AI summaries, deadline alerts and a bid pipeline for tenders matched to your business. Free to start. 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