Source: https://tendernation.io/opportunities/01a13cad-1fa1-70db-ba6e-dc64655b3168/integrated-bioreactor-platform-for-rapid-scale-up-and-translation closed GB open procedure Suitable for SMEs # Integrated bioreactor platform for rapid scale-up and translation [The University of Manchester](https://tendernation.io/buyers/the-university-of-manchester) Estimated value Not stated Published 24 Apr 2023 Deadline Closed 25 May 2023 ## Who can bid - Buyer says suitable for SMEs The buyer ticked “suitable for SMEs” on the notice. Anyone can still bid. - Open procedure Anyone can submit a full tender; there is no shortlisting stage. [More contracts for small businesses and VCSEs](https://tendernation.io/opportunities/for-small-businesses) ## About this tender This tender is being run on behalf of Dr James Winterburn, Reader in Chemical Engineering. Dr Winterburn led a successful BBSRC ALERT21 equipment bid "Integrated bioreactor platform for rapid scale-up and translation", which will provide significant bioreactor capacity for microbial fermentation process development, scale up and translation for a range of bio-based chemicals. The exploitation of bio-based production routes requires a thorough understanding of production strain performance and an ability to rapidly and effectively scale processes from millilitres to tens of litres. The bioreactor platform is intended to provide understanding of how process conditions at different volumes and variability across process parameters (e.g., mixing speeds, dissolved O2, pH), affect host cell performance. The integrated bioreactor platform will bridge across three scales, outlined below, and allow for rapid process development and ultimately support research translation. ï‚· Small-scale: Parallel bioreactor system (500 mL, 6 vessels) for rapid parallel process development, strain testing and parameter optimization for microbial fermentations in batch, fed-batch and continuous cultivation, with off gas analysis capability ï‚· Mid-scale (3L bioreactor system, four vessels): For initial scale up and process development work (e.g., confirmation of feeding profiles, metabolic profiling) and preliminary process analysis (including; yield, productivity, final titre) with off gas analysis capability. Also serves as the seed train for inoculum preparation for scale up to 40L. ï‚· Large-scale feasibility (40L SIP bioreactor): To enable in-house demonstration of process technical feasibility, production of sufficient quantities of material for application testing and benchmarking and provision of data for robust techno-economic analysis which can be used as the basis for commercialisation, also with off gas analysis capability. Additional information: Information, formalities and necessary requirements to be met will be set out in the procurement documents, all of which are available via the University`s procurement portal In-Tend - [in-tendhost.co.uk/manchesteruniversity](https://in-tendhost.co.uk/manchesteruniversity) Is a Recurrent Procurement Type? : No Read full description ## CPV classification Chemical industry machinery Source Contracts Finder (UK) [View official notice](https://www.contractsfinder.service.gov.uk/notice/11896b9a-3ab9-452a-b23c-b2855106b915) Never miss a tender like this again Get AI summaries, deadline alerts and a bid pipeline for tenders matched to your business. Free to start. 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