Source: https://tendernation.io/opportunities/01a13c2d-4f61-71aa-9cf7-ef5a1c77bab8/multiwave-automated-ultra-centrifuge-itt996 closed GB open procedure # Multiwave Automated Ultra Centrifuge\_ITT996 [The University of Nottingham](https://tendernation.io/buyers/the-university-of-nottingham) Estimated value Not stated Published 21 May 2018 Deadline Closed 18 Jun 2018 ## Who can bid - Open procedure Anyone can submit a full tender; there is no shortlisting stage. ## About this tender Analytical Ultracentrifuge with UV/Visible and Interference Optics UoN seeks proposals for a method of determining the molecular properties of proteins, nucleic acids and protein complex interactions. In the event our laboratory direction includes complexes such as monoclonal antibodies, carbohydrates, polysaccharides and polymers, it is highly desirable that any proposed instrument is capable of including these compounds. The instrumentation must be capable of providing the following essential characteristics: · The nature of the separation be able to determine the weight or other molecular properties of the molecule in solution based on first-order thermodynamics (i.e. a sample subjected to a carefully controlled centrifugal force), so that the behaviour of the solute molecule can be recorded to determine various properties without disturbance of the original sample by additions of standards (i.e. maintain absolute data integrity free of internal standards). · The analytical ultracentrifugation needs to provide a rapid and highly accurate quantitative determination of association/dissociation behaviours. In addition to a determination of molecular weight, this technique needs to be able to directly determine other coefficients such as sedimentation diffusion coefficients. · The instrumentation technique proposed needs to be non-destructive (i.e. does not disrupt binding activity, to biocompatible buffer systems) and therefore provides a method to observe and record molecular binding phenomena. · The instrumentation technique must enable recovery of samples. · A dual optical system is required that includes both UV/Visible optics and interference optics to extend the sample concentration range to lower and higher levels than UV/Vis optics. Many of our protein samples provide little absorbance in the UV range and/or require solvents that interfere with the protein's absorbance in the UV range. Interference optics needs to operate independently of a sample's absorbance in the UV/Visible range and should not is not affected by a solvent's absorbance. In addition, a linear detection range for interference optics is required to permit permit accurate determination for our high concentration nucleotide samples. ### IMPORTANT NOTE: Installation Site details ### Delivered to (RCaH) the Research Complex at Harwell Located on the Rutherford Appleton Laboratory (RAL) site On the Harwell Research and Innovation complex 168 Maxwell Ave, Didcot Oxford OX11 Additional information: TENDERERS MUST EXPRESS THEIR INTEREST THROUGH FIRST REGISTERING ON THE UNIVERSITY`S E-TENDERING SYSTEM [in-tendhost.co.uk/universityofnottingham](https://in-tendhost.co.uk/universityofnottingham/) Non-compliant expressions of interest (EOI) will not be considered or acknowledged. The university reserves the right to cancel the tender process at any stage. The University does not accept any liability for any costs incurred in tenderingEXPRESSIONS OF INTEREST CLOSE: 04 December 2014 To EXPRESS INTEREST: Please first register on the eTendering system then Login and go to Tenders. Find the project scroll down to View Details and then scroll down to the Express Interest` button at the foot on the right hand side. NOTE: To make sure you receive our email notifications. to ensure our emails reach your inbox please add our email domain @in-tend.co.uk to your safe senders list and check your spam filter settings.. Once you have registered, log-in and go to Current Tenders/view printable details, then expressed interest in the project. Once you have registered, expressed interest in the project AND your EOI will be accepted and an email will automatically be sent notifying you (to the inserted publish email address at point of registration) that it has been accepted and a second email notifying you that the documents have been published to your site under `My Tenders`. Internet Explorer (not Mozilla Firefox) should be used and pop ups must be allowed. All correspondence relating to this project should only be made through the e-Tendering web site. Click on CREATE NEW CORRESPONDENCE once you have logged on to the Web site and follow the instructions. Select send message via web option rather than `by email` option as this is received by the host company not directly to UoN. HELP?: Should you encounter any problems with using the Web site (including if you get locked out), contact the In-Tend Help Desk on 0844 272 8810 Is a Recurrent Procurement Type? : No Read full description ## CPV classification Laboratory, optical and precision equipments (excl. glasses) Source Contracts Finder (UK) [View official notice](https://www.contractsfinder.service.gov.uk/notice/c40ac323-4ed0-41f4-bfe8-b2730388a45c) Never miss a tender like this again Get AI summaries, deadline alerts and a bid pipeline for tenders matched to your business. Free to start. 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