Source: https://tendernation.io/opportunities/01a13c01-4804-7268-914c-226965dfcfb0/nkp46cd3-cells-as-a-novel-target-for-vaccines-against-bovine-tb awarded GB open procedure Suitable for SMEs # NKp46+CD3+ cells as a Novel Target for Vaccines Against Bovine TB [Department for Environment, Food & Rural Affairs](https://tendernation.io/buyers/department-for-environment-food-rural-affairs) Estimated value £258,467 Published 18 Nov 2016 Deadline Closed 1 Mar 2016 ## Who can bid - Buyer says suitable for SMEs The buyer ticked “suitable for SMEs” on the notice. Anyone can still bid. - Buyer says suitable for VCSEs The buyer ticked “suitable for voluntary, community and social enterprises” on the notice. - Open procedure Anyone can submit a full tender; there is no shortlisting stage. [More contracts for small businesses and VCSEs](https://tendernation.io/opportunities/for-small-businesses) ## About this tender The Morrison and Vordermeier laboratories have recently identified a novel NKp46+CD3+ non-conventional T-cell population in cattle and demonstrated that a subset of these cells recognise phosphatidylinositol mannosides (PIMs - a group of membrane bound lipids) from Mb. In this project we propose to i) examine NKp46+CD3+ T-cell responses during a BCG-immunisation/Mb-challenge study so as to gain some insights into the role of lipid-specific T-cells in bTB and ii) explore the breadth of lipids from TB that act as antigens for bovine T-cells and evaluate their potential as vaccine antigens. Specifically we aim to address the following questions: - What are the quantitative and kinetic characteristics of the NKp46+CD3+ T-cell response following BCG vaccination and subsequent exposure to M. bovis? - What are the functions of NKp46+CD3+ T-cells recognising mycobacteria? - Which mycobacterial lipids are recognised by NKp46+CD3+ (and other) bovine T-cells? - Can vaccination with mycobacterial lipid extracts elicit NKp46+CD3+ T-cell responses in vivo? The combined results of the proposed studies will provide the fundamental basic immunological data to determine if inclusion of lipid antigens has the potential to enhance the immunogenicity and protective efficacy of new bTB vaccines. We also will perform analyses to define if lipid antigens could be used as novel DIVA reagents. Additional information: Please note that Defra procurement uses e-tendering, provided by Bravosolutions. In order to access the Bravo system you will need to be registered. Could I therefore request that you register on the Bravo portal for Defra. If you’re already registered on the Bravo portal please check that your registration includes Defra, as you have to specify us in order to correctly receive the tender documents. If you have any problems with the registration process, please contact the Bravo helpline on 0800 368 4850 or alternatively email them at . The link you require for new registration/amendments to registrations is - [defra.bravosolution.co.uk](https://defra.bravosolution.co.uk) Read full description ## CPV classification General anti-infectives for systemic use and vaccines Source Contracts Finder (UK) [View official notice](https://www.contractsfinder.service.gov.uk/notice/bb9218d8-adc9-11e6-9901-0019b9f3037b) Never miss a tender like this again Get AI summaries, deadline alerts and a bid pipeline for tenders matched to your business. Free to start. 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