Source: https://tendernation.io/opportunities/01a13bbf-fe73-72f6-916f-39b53cafdeb2/utilising-in-silico-in-vitro-and-omics-new-approach-methodologies-nams-for-p awarded GB direct award procedure Suitable for SMEs # Utilising in silico, in vitro and ‘omics New Approach Methodologies (NAMs) for priority-setting and safety assessment of tropane alkaloids (TAs) and other plant toxins as potential food contaminants. A case study for progressing the acceptance of NAMs for [Food Standards Agency](https://tendernation.io/buyers/food-standards-agency) Estimated value Not stated Published 27 Oct 2025 Deadline Rolling deadline ## Who can bid - Buyer says suitable for SMEs The buyer ticked “suitable for SMEs” on the notice. Anyone can still bid. - Buyer says suitable for VCSEs The buyer ticked “suitable for voluntary, community and social enterprises” on the notice. [More contracts for small businesses and VCSEs](https://tendernation.io/opportunities/for-small-businesses) ## About this tender Tenders were invited to carry out a range of project delivery options, to deliver against stages 1, 2 and 3 as described below: Stage 1: This case study is to support the UK FSA’s policy need to determine which TAs are the most potent (neuro)toxicants so as to prioritise specific substances and inform decisions on the UK’s monitoring of these alkaloids in foods. An integral part of this aim is to confirm that neurotoxicity is the primary mode of action of these alkaloids. This aim will be achieved using a tiered-testing strategy of in silico, in vitro and ‘omics NAMs. This will then be extended to other plant alkaloids such as glycoalkaloids and pyridazine alkaloids. Stage 2: To derive a HBGV for human exposure for the top priority, i.e. most potent substance within the class of TAs. This will utilise physiologically-based kinetic (PBK) modelling and quantitative in vitro to in vivo extrapolation (QIVIVE). This will then be extended to other plant alkaloids such as glycoalkaloids and pyridazine alkaloids. Stage 3: From a methodological perspective, a broader third objective of the case study is to evaluate and attempt to build confidence within the FSA in the application of a series of relevant NAMs that have been integrated in a manner to address policy needs. These NAMs are tiered and incorporate existing human in vivo data as well as new testing on human in vitro cell lines, to maximise the relevance and accuracy to human food safety. Please note contract start date is 22/09/2025 Read full description Source Find a Tender (UK) · Notice ocds-h6vhtk-0565d3-2025-10-27T15:26:01Z [View official notice](https://www.find-tender.service.gov.uk/Notice/ocds-h6vhtk-0565d3-2025-10-27T15:26:01Z) Never miss a tender like this again Get AI summaries, deadline alerts and a bid pipeline for tenders matched to your business. Free to start. [Track tenders free](https://tendernation.io/register) [Buyer profile Food Standards Agency: past awards and live tenders](https://tendernation.io/buyers/food-standards-agency) ## More tenders like this [Bannister Sports Centre Athletic Track Soft Market Testing Exercise · Harrow Council · 38 days left · 26 Nov 2026](https://tendernation.io/opportunities/01a1540d-d9e4-71cb-ad57-1603e9042fec/bannister-sports-centre-athletic-track-soft-market-testing-exercise) [Hdc-1714 wadkins pavilion refurbishment · Harborough District Council · 39 days left · 27 Nov 2026](https://tendernation.io/opportunities/01a155bf-f664-72f9-9823-a85d6cddbdc6/hdc-1714-wadkins-pavilion-refurbishment) [Design, supply, and Installation of Newbiggin Skatepark Extension · Newbiggin Town Council · 35 days left · 23 Nov 2026](https://tendernation.io/opportunities/01a15552-19a2-7348-a5cc-3f5ae51ef934/design-supply-and-installation-of-newbiggin-skatepark-extension) [Tender for the design, supply, delivery and installation of a modular UNIT and associated works at ARC healthy living, irvinestown. peaceplus funded upgrade works · Fermanagh and Omagh District Council · 14 days left · 2 Nov 2026](https://tendernation.io/opportunities/01a15552-1b74-73ec-a6f6-a1af37959997/tender-for-the-design-supply-delivery-and-installation-of-a-modular-unit-and-a) [Architectural, design and building consultancy services - Dalby Visitor Centre · Forestry Commission · 25 days left · 13 Nov 2026](https://tendernation.io/opportunities/01a15552-1b8a-7041-80fb-e4943876fc38/architectural-design-and-building-consultancy-services-dalby-visitor-centre) [QW Planned and Reactive Facilities Management Services · Qualifications Wales · 42 days left · 30 Nov 2026](https://tendernation.io/opportunities/01a15552-1c32-72a6-a86e-45f144e2f84b/qw-planned-and-reactive-facilities-management-services)